API TR 411-1996

$29.25

Chinese Hamster Ovary (CHO)/HGPRT Mutation Assay of Tertiary Amyl Methyl Ether (TAME)

Published By	Publication Date	Number of Pages
API	1996	44

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Description

The test article, Tertiary Amyl Methyl Ether (TAME), was tested in the CHO/HGPRT Mutation Assay in the absence of Aroclor-induced rat liver S9 at doses of 1000 to 5000 pg/ml and in the presence of Aroclor-induced rat liver S9 at doses of 500 to 5000 pg/ml. No positive responses, i.e., treated cultures with mutant frequencies >40 mutants per 10b clonable cells, were observed. All concentrations were soluble in treatment medium. Toxicity, i.e., cloning efficiency 50 V0 of the solvent control, was observed at doses of 4000 and 5000 pg/ml with S9 activation. Under the conditions of this study, test article Tertiary Amyl Methyl Ether (TAME) was concluded to be negative in the CHO/HGPRT Mutation Assay.

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