API PUBL 4647-1997

$25.35

Brain Glial Fibrillary Acidic Protein (GFAP) as a Marker of Neurotoxicity During Inhalation Exposure to Toluene

Published By	Publication Date	Number of Pages
API	1997	50

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Description

Glial fibrillary acidic protein (GFAP) was measured during and after sub-chronic exposure to toluene. Rats received inhalation exposure to air or 100-3,000 ppm toluene, 6 hr/day, 5 days/wk for up to 42 days. Toluene, in concentrations that are low for the rat (100 to 1,000 ppm), altered GFAP and motor behavior without affecting body weight or producing overt signs of neurotoxicity. However, the declines in GFAP concentration during toluene exposure differ from the more commonly reported toxicant-induced pattern of increased GFAP. At a higher concentration (3,000 ppm), toluene produced increased GFAP concentrations, observable neurological signs and weight loss. These results are discussed in relation to methodological issues and the relevant scientific literature. GFAP can provide an index of toxicity, even with exposures below the level which produce overt signs of toxicity. For toxicity screening with animals, a battery including GFAP as well as behavioral and neurochemical measures would be useful. Implications for future research are discussed.

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