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BS ISO 22186:2020

BS ISO 22186:2020

$142.49

Milk and milk products. Determination of nitrofurazone

Published By Publication Date Number of Pages
BSI 2020 30
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This document specifies a liquid chromatography tandem mass spectrometry (LC–MS/MS) method for the quantification of the inhibitory substance, nitrofurazone, in milk and milk products.

The method has been validated for measuring trace levels of intact nitrofurazone to levels down to 1 ng/g in fluid milk and powdered dairy products on a whole product (i.e. powder) basis. While the method is expected to apply to other dairy matrices, additional validation will be required to demonstrate this.

PDF Catalog

PDF Pages PDF Title
2 National foreword
7 Foreword
9 Introduction
11 1 Scope
2 Normative references
3 Terms and definitions
4 Principle
12 5 Reagents and reference substances
5.1 Reagents and materials
13 5.2 Reference substances
14 5.2.7 Standard solutions for calibration by the external calibration curve approach.
5.2.8 Solutions for LC–MS/MS.
15 6 Apparatus
7 Sampling
16 8 Procedure
8.1 Test portion
8.1.1 Liquid milk
8.1.2 Powdered dairy products
8.2 Extraction procedure
8.3 Reagent blank
17 8.4 Positive quality control
8.4.1 General
8.4.2 Liquid milk
8.4.3 Powdered dairy products
8.4.4 Calculations
8.5 Matrix-matched calibration curves
8.5.1 General
18 8.5.2 Matrix-matched calibration samples for fluid milk
8.5.3 Matrix-matched calibration samples for powdered dairy products
8.6 LC–MS/MS conditions
8.6.1 General
8.6.2 Chromatographic conditions
19 8.6.3 MS/MS conditions
20 8.7 Sequence set-up
9 Calculation and expression of results
9.1 General
9.2 Peak integration
21 9.3 Calibration curves
9.3.1 External calibration curve from external calibration standards
9.3.2 Matrix-matched calibration curve from matrix-matched calibration standards
9.4 Identification and confirmation
9.5 Calculation using external calibration curve
22 9.6 Calculation using matrix-matched calibration curve
9.7 Expression of results
10 Precision
10.1 General
10.2 Repeatability
23 10.3 Reproducibility
11 Test report
24 Annex A (informative) Examples of chromatograms
25 Annex B (informative) Precision data
29 Bibliography

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BS ISO 22186:2020
$142.49