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BSI 22/30437105 DC:2022 Edition

BSI 22/30437105 DC:2022 Edition

$13.70

BS ISO 19238. Radiological protection. Performance criteria for service laboratories performing biological dosimetry by cytogenetics. The dicentric assay

Published By Publication Date Number of Pages
BSI 2022 48
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PDF Catalog

PDF Pages PDF Title
1 30437105-NC.pdf
3 ISO_DIS 19238 ed.3 – id.82295 Enquiry PDF (en).pdf
7 Foreword
8 Introduction
9 1 Scope
2 Normative references
3 Terms and definitions
11 4 Abbreviated terms
12 5 Dicentric assay
6 Responsibility of the requestor
13 7 Responsibility of the service laboratory
7.1 Setup and sustainment of the QA program
7.2 Responsibility during service
14 8 Confidentiality of personal information
8.1 Overview
8.2 Applications of the principle of confidentiality
8.2.1 Delegation of responsibilities within the laboratory
15 8.2.2 Requests for analysis
8.2.3 Transmission of confidential information
8.2.4 Anonymity of samples
8.2.5 Reporting of results
8.2.6 Storage
8.2.7 Data Security Plan
9 Laboratory safety requirements
9.1 Overview
16 9.2 Microbiological safety requirements
9.3 Chemical safety
17 9.4 Optical safety requirements
9.5 Safety plan
10 Sample processing
10.1 Culturing
18 10.2 Scoring
10.2.1 Coding of samples and slides
10.2.2 Scoring techniques
10.2.3 Procedure for scoring first-division metaphases
19 10.2.4 Laboratory scoring expertise
11 Calibration Curves
11.1 Calibration source(s)
11.2 Establishment of calibration curve(s)
21 12 Criteria for converting a measured aberration frequency into an estimate of absorbed dose
12.1 General
12.2 Testing the distribution of aberrations per cell
22 12.3 Comparison with the background level: Characterisation of the minimum detectable dose
24 12.4 Confidence limits on the number of dicentrics
25 12.5 Calculation of absorbed dose for whole-body exposures
12.6 Calculation of uncertainty on absorbed dose
26 12.7 Acute and non-acute exposure cases
12.8 Partial body and prior exposure cases
28 12.9 Other exposure scenarios
13 Reporting of results
13.1 General
13.2 Content of the report (see Annex€C for a standard form)
13.3 Interpretation of the results
29 14 Quality assurance and quality control
14.1 Overview
14.2 Specific requirements
14.2.1 General
14.2.2 Performance checks by laboratory inter-comparisons
30 14.2.3 Periodical performance check of scorer qualification
14.2.4 Performance checks of sample transport integrity
31 14.2.5 Performance checks of sample integrity by service laboratory
14.2.6 Performance checks for instrumentation
14.2.7 Performance checks of sample protocol
14.2.8 Performance checks of sample scoring
14.2.9 Performance checks of dose and confidence limits estimation
14.2.10 Performance checks for result report generation
33 Annex€A (informative) Sample instructions for requestor
35 Annex€B (informative) Sample questionnaire
37 Annex€C (informative) Sample of report
39 Annex€D (informative) Fitting of the low-LET dose-response curve by the method of maximum likelihood and calculating the error of dose estimate
42 Annex€E (informative) Odds ratio method for cases of suspected exposure to a low dose
44 Annex€F (informative) Decision threshold and detection limit
47 Annex€G Sample data sheet for recording aberrations
48 Bibliography

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