{"id":381837,"date":"2024-10-20T03:13:21","date_gmt":"2024-10-20T03:13:21","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/bs-en-iso-216762021\/"},"modified":"2024-10-26T05:51:20","modified_gmt":"2024-10-26T05:51:20","slug":"bs-en-iso-216762021","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/bsi\/bs-en-iso-216762021\/","title":{"rendered":"BS EN ISO 21676:2021"},"content":{"rendered":"

This document specifies a method for the determination of the dissolved fraction of selected active pharmaceutical ingredients and transformation products, as well as other organic substances (see Table 1) in drinking water, ground water, surface water and treated waste water.<\/p>\n

The lower application range of this method can vary depending on the sensitivity of the equipment used and the matrix of the sample. For most compounds to which this document applies, the range is \u2265 0,025 \u00b5g\/l for drinking water, ground water and surface water, and \u2265 0,050 \u00b5g\/l for treated waste water.<\/p>\n

The method can be used to determine further organic substances or in other types of water (e.g. process water) provided that accuracy has been tested and verified for each case, and that storage conditions of both samples and reference solutions have been validated. Table 1 shows the substances for which a determination was tested in accordance with the method. Table E.1 provides examples of the determination of other organic substances.<\/p>\n

Table 1<\/b><\/p>\n

Substances for which a determination was tested in accordance with this method<\/b><\/p>\n

a<\/sup> IUPAC: International Union of Pure and Applied Chemistry.<\/p>\n

b<\/sup> CAS-RN: Chemical Abstracts System Registration Number.<\/p>\n

PDF Catalog<\/h4>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
PDF Pages<\/th>\nPDF Title<\/th>\n<\/tr>\n
2<\/td>\nundefined <\/td>\n<\/tr>\n
6<\/td>\nForeword <\/td>\n<\/tr>\n
7<\/td>\nIntroduction <\/td>\n<\/tr>\n
9<\/td>\n1 Scope <\/td>\n<\/tr>\n
12<\/td>\n2 Normative references
3 Terms and definitions
4 Principle
5 Interferences
5.1 During sample preparation
5.2 During high performance liquid chromatography and mass spectrometry <\/td>\n<\/tr>\n
13<\/td>\n6 Reagents
6.1 General
6.2 Preparation of solutions <\/td>\n<\/tr>\n
15<\/td>\n7 Apparatus <\/td>\n<\/tr>\n
16<\/td>\n8 Sampling
9 Procedure
9.1 General
9.2 Sample preparation <\/td>\n<\/tr>\n
17<\/td>\n9.3 High performance liquid chromatography (HPLC)
9.4 Detection
9.4.1 General <\/td>\n<\/tr>\n
18<\/td>\n9.4.2 Tandem mass spectrometry (MS\/MS)
9.4.3 High-resolution mass spectrometry (HRMS)
9.5 Blank value measurements
10 Calibration
10.1 General <\/td>\n<\/tr>\n
20<\/td>\n10.2 Calibration with external standard
10.3 Calibration with internal standard <\/td>\n<\/tr>\n
21<\/td>\n11 Calculation of recovery
11.1 General
11.2 Calculation of analyte recovery using samples <\/td>\n<\/tr>\n
22<\/td>\n11.3 Recovery of internal standards
12 Evaluation
12.1 Verification of individual substances <\/td>\n<\/tr>\n
23<\/td>\n12.2 Calculation of the individual results using calibration with an external standard
12.3 Calculation of the individual results using calibration with an internal standard <\/td>\n<\/tr>\n
24<\/td>\n13 Expression of results
14 Test report <\/td>\n<\/tr>\n
25<\/td>\nAnnex A (informative) Performance data <\/td>\n<\/tr>\n
30<\/td>\nAnnex B (informative) Examples of recovery <\/td>\n<\/tr>\n
32<\/td>\nAnnex C (informative) Examples of HPLC columns and chromatograms <\/td>\n<\/tr>\n
38<\/td>\nAnnex D (informative) Examples of detection <\/td>\n<\/tr>\n
41<\/td>\nAnnex E (informative) Examples of extension of the method <\/td>\n<\/tr>\n
42<\/td>\nBibliography <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Water quality. Determination of the dissolved fraction of selected active pharmaceutical ingredients, transformation products and other organic substances in water and treated waste water. Method using high performance liquid chromatography and mass spectrometric detection (HPLC-MS\/MS or -HRMS) after direct injection<\/b><\/p>\n\n\n\n\n
Published By<\/td>\nPublication Date<\/td>\nNumber of Pages<\/td>\n<\/tr>\n
BSI<\/b><\/a><\/td>\n2021<\/td>\n44<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":381845,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[216,2641],"product_tag":[],"class_list":{"0":"post-381837","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-13-060-50","7":"product_cat-bsi","9":"first","10":"instock","11":"sold-individually","12":"shipping-taxable","13":"purchasable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/381837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/381845"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=381837"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=381837"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=381837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}