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ASTM-E1280:2008 Edition

ASTM-E1280:2008 Edition

$40.63

E1280-97(2008) Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity

Published By Publication Date Number of Pages
ASTM 2008 9
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ASTM E1280-97-Reapproved2008

Withdrawn Standard: Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity (Withdrawn 2015)

ASTM E1280

Scope

1.1 The purpose and scope of this guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK+/−-3.7.2C mouse lymphoma mutagenicity assay (commonly referred to as the mouse lymphoma assay, (MLA)) can be properly understood and evaluated. This guide is also intended to aid researchers and others to gain a better understanding of the critical elements involved with mammalian cell mutagenicity testing. More specifically, this guide is intended to provide for researchers the accomplishment of the following goals:

1.1.1 Provide an understanding of the critical procedures (steps) in the performance of this mammalian cell mutagenicity test.

1.1.2 Provide generalized criteria by which researchers can evaluate if they are properly performing, utilizing, and interpreting this assay.

1.1.3 Provide criteria by which individuals responsible for evaluating MLA data can determine if the experiments have been properly performed and interpreted.

1.1.4 Provide a basis from which new procedures and developments in testing procedures can be evaluated.

1.1.5 Provide an understanding of the types of genetic damage (that is, gene and chromosome mutation) that may be detected in this mammalian cell mutagenicity test.

1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

Keywords

Assay; Carcinogenicity; Chromosomal/genetic effects; Cloning; Cytotoxicity; Data analysis–environmental; Genetic examination; Mammalian cell mutagenicity; Metabolic activation; Mice; MLA (mouse lymphoma assay); Mutagenicity; Plating (cloning) efficiency; Quality assurance (QA)–environmental; Solubility; Spontaneous (background) mutant frequency; Test animals; THMG cleansing; Testing methods; Total growth; Toxicity/toxicology–animals

ICS Code

ICS Number Code 07.100.10 (Medical microbiology)

DOI: 10.1520/E1280-97R08

PDF Catalog

PDF Pages PDF Title
1 Scope
Terminology
2 Significance and Use
Test Materials
3 Test Method
5 Test Data
7 Test Report
8 REFERENCES

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