{"id":302724,"date":"2024-10-19T20:41:06","date_gmt":"2024-10-19T20:41:06","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/bsi-pd-iso-tr-220192019\/"},"modified":"2024-10-25T18:12:57","modified_gmt":"2024-10-25T18:12:57","slug":"bsi-pd-iso-tr-220192019","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/bsi\/bsi-pd-iso-tr-220192019\/","title":{"rendered":"BSI PD ISO\/TR 22019:2019"},"content":{"rendered":"

This document describes the background and principles for toxicokinetic studies relevant for nanomaterials.<\/p>\n

Annex A<\/span> shows the definitions for terminology with respect to toxicokinetics as used in OECD TG 417:2010.<\/p>\n

PDF Catalog<\/h4>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
PDF Pages<\/th>\nPDF Title<\/th>\n<\/tr>\n
2<\/td>\nNational foreword <\/td>\n<\/tr>\n
6<\/td>\nForeword <\/td>\n<\/tr>\n
7<\/td>\nIntroduction <\/td>\n<\/tr>\n
9<\/td>\n1 Scope
2 Normative references
3 Terms and definitions <\/td>\n<\/tr>\n
11<\/td>\n4 Abbreviations
5 Importance of toxicokinetic information for risk assessment of nanomaterials
5.1 General <\/td>\n<\/tr>\n
12<\/td>\n5.2 Possible use of toxicokinetic information <\/td>\n<\/tr>\n
13<\/td>\n5.3 Key toxicokinetic issues for nanomaterials
6 Factors influencing the toxicokinetics of nanomaterials
6.1 Dissolution rate <\/td>\n<\/tr>\n
14<\/td>\n6.2 Physical chemical properties determinant for toxicokinetic behavior <\/td>\n<\/tr>\n
18<\/td>\n7 Analytical challenges
7.1 General
7.2 Analysis of element <\/td>\n<\/tr>\n
19<\/td>\n7.3 Analysis of element radiolabel or fluorescence label <\/td>\n<\/tr>\n
20<\/td>\n7.4 Determination of particles <\/td>\n<\/tr>\n
21<\/td>\n7.5 Limit of detection
8 Issues relevant for dosing conditions
8.1 General <\/td>\n<\/tr>\n
22<\/td>\n8.2 Dose metrics <\/td>\n<\/tr>\n
23<\/td>\n9 Absorption of nanomaterials
9.1 General
9.2 Skin <\/td>\n<\/tr>\n
24<\/td>\n9.3 Gastrointestinal (GI) tract <\/td>\n<\/tr>\n
26<\/td>\n9.4 Respiratory tract <\/td>\n<\/tr>\n
30<\/td>\n10 Distribution
10.1 General
10.2 Organ distribution <\/td>\n<\/tr>\n
31<\/td>\n10.3 Transport across the placenta, BBB and to reproductive organs <\/td>\n<\/tr>\n
32<\/td>\n11 Metabolism\/degradation
12 Excretion <\/td>\n<\/tr>\n
33<\/td>\n13 Conclusions <\/td>\n<\/tr>\n
37<\/td>\nAnnex A (informative) Definitions as used in OECD Test Guideline 417:2010 <\/td>\n<\/tr>\n
40<\/td>\nAnnex B (informative) Quantitation methods for nanomaterials, advantages and challenges <\/td>\n<\/tr>\n
47<\/td>\nBibliography <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Nanotechnologies. Considerations for performing toxicokinetic studies with nanomaterials<\/b><\/p>\n\n\n\n\n
Published By<\/td>\nPublication Date<\/td>\nNumber of Pages<\/td>\n<\/tr>\n
BSI<\/b><\/a><\/td>\n2019<\/td>\n64<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":302730,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[2641],"product_tag":[],"class_list":{"0":"post-302724","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bsi","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/302724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/302730"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=302724"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=302724"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=302724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}